Synthesis of MDP2P without Safrole

the Hive BB

Chemistry Discourse

profile | register | preferences | faq | search

next newest topic | next oldest topic

Author	Topic: Synthesis of MDP2P without Safrole
APOPLEX Hive Bee	posted 01-13-2000 02:08 PM Hello to all bees Buying Safrol, Isosafrole or Safrole containing Essential Oils is very dangerous or sometimes impossible today. You should know why..... There are some ways to synthesize the above compounds in the Build from Scratch section in TS II, but no direct synth. of MDP2P. So I think this should discussed here. My thoughts of it..... 1. Friedel-Crafts-Acylation: Pyrocatechole (PC) and a halide-Ketone like Bromoacetone are reacting to MDP2P via a Lewis Acid like or SnCl2 or SnCl4?. Perhaps AlCl3 will work, if it is not to strong. I don`t know. To prepare Bromoacetone see Rhodiums Chemistry Archive. 2. Methylation: This intermediate is methylated with DCM and NaOH in DMSO like described in TS II. In my opinion this should give MDP2P But some disadvantages..... Bromoacetone is a fucking nasty teargas, to work with is could be really dangerous. So, that`s it for today. And to all bees.... Let`s work together to find a synthesis of this special Ketone, best without such things like Bromoacetone, because the sources of Safrole are going down the drain.... ------------------- APOPLEX
APOPLEX Hive Bee	posted 01-14-2000 09:59 PM Hey, bees ! Two days and NO posts or ideas ? Come on, let`s discuss a little bit... ----------------- APOPLEX
iudexk Hive Bee	posted 01-15-2000 08:00 AM 1. piperonyl alcohol ---> piperonal K2Cr2O7/H2SO4, or maybee KMnO4? I suggest piperonyl alc. because it is cheap, and not listed so [can bee bought, from all "good " chemical retailers. 2. piperonal + EtNO2 -> MDP2nP Mobius rxn catalysed by cHexylNH2, yield=90+% 3. MDP2nP -> MDP2P Fe/GAA or Fe/HCl, high yields. Sweet dreams, IudexK
Biscuit Hive Bee	posted 01-15-2000 06:24 PM i have nothing decent to add other than i feel in a few years this is where the money will be made. similar to the poppy fields of asia, etc i think u'll have people setting up huge sassafras plantations, extracting the oil and selling pure distilled safrole on the black market, at enormous prices, thats where i see it going. then others will make the MDMA but as this may be the only decent source of safrole one day, these people will reap huge rewards without the concern of manufacturing and distributing the drugs.
Wizard X PimpBee	posted 01-15-2000 08:50 PM APOPLEX: Cubebin, Merck 11ed pg 409, No. 2616 One mole of cubebin makes approx 2 moles of piperonal.
APOPLEX Hive Bee	posted 01-16-2000 08:27 AM Iudexk: Could you please e-mail me some good sources for the Piperonyl alc. ? My address: Apoplex@hushmail.com Thanx ---------------------- APOPLEX
sparks Hive Bee	posted 01-18-2000 02:43 AM iudexk, etNO2 is even more difficult to get than safrole. At least in europe as it don't have much use to ordinary people. It also was used for decades to make P2NP, used in the old electrolytic basement amphetamine method. That makes etNO2 a very risky compound to purchase, at least around my parts of the nuclear wastelands.
iudexk Hive Bee	posted 01-18-2000 07:08 AM But you can make it from OTC. Its worth it if u do it large-scale.
sparks Hive Bee	posted 01-18-2000 07:55 AM Propane and NO2 or? Could be worth it as bensaldehyde is just about everywhere. That electrolytic reduction is really simple and except for the Hg more or less OTC.
iudexk Hive Bee	posted 01-18-2000 01:28 PM See Rhodium's nitroalkane synth FAQ. Hg is OTC as well.
mnm Hive Bee	posted 01-18-2000 01:40 PM Sure is! Hg can still be found in some thermometers and definitly in electronic "tilt" switches. (so goto your local electronics surplus supply shop and pick up a couple of grams today!) -mnm
rev drone Hive Bee	posted 01-18-2000 02:33 PM This is the topic of numerous threads. One procedure of interest is the synthesis of MDP-2-P from eugenol or isoeugenol, which entails a demethylation and methylenation(1,3-dioxyltion) sequence of steps. There are numerous other means ------------------ -the good reverend drone Ipsa scientia potestas est
APOPLEX Hive Bee	posted 01-18-2000 06:26 PM rev drone: Eugenole is also out in my country. These are the List I Chemicals at my location: Ephedrine and Pseudoephedrine Ergometrine Ergotamine Lysergic-acid (LSA) P2P N-Acetyleanthranile-acid MDP-2-P Piperonale (Heliotropine) Egenole and Isoeugenole Safrole, Isosafrole (cis+trans) ... and all salts and isomeres, if they could be exist. Also all Essential Oils that contain one of the above compund. FUCK THAT SHIT So, any useable method making the Ketone without the above compounds and it`s derivates should earn a Nobel Price ! ------------------- APOPLEX
Osmium PimpBee	posted 01-19-2000 05:07 AM Impossible. Eugenol can't be regulated. I highly doubt that. Which country are we talking about? Email me if you don't want to post it here.
sparks Hive Bee	posted 01-19-2000 05:45 AM In europe Hg and Hg salts is very difficult to get (unless you have some sources the authoroties haven't thought of yet ). You cant even buy a Hg-thermometer without a special permit anymore.
rev drone Hive Bee	posted 01-19-2000 10:34 AM There's no country on the planet that regulates eugenol. Still, if you're in one of those itty-bitty European countries (which aren't even real countries anyways), then I'd suggest vanillin as a starting material, convering it to piperonal, then condensing it with nitroethane, and reducing it. Don't even tell me vanillin is controlled, or I will have to inform you that you're either A) nuts, B) a citizen of a REALLY stupid country, or C) all of the above. I just have a hard time believing any country that doesn't regulate nitroethane would regulate eugenol; it just doesn't make sense. ------------------ -the good reverend drone Ipsa scientia potestas est
iudexk Hive Bee	posted 01-19-2000 12:34 PM Sparks wrote: You cant even buy a Hg-thermometer without a special permit anymore. Which country are you talking about? Hg thermometers are all over the place in UK, but buying/importing Hg salts is v. hard because of the IRA (merc. fulminate).
APOPLEX Hive Bee	posted 01-19-2000 01:01 PM Ok, this was a BIG typo from me, sorry ! Please don`t send me to the NewBee Forum for this typo Eugenole isn`t controlled in my country The rest is going to rev drone for his post: A) So, I´m not nuts - perhaps a little bit B) If you ONLY talking about our laws, you are ablolutely right. C) Nep BTW: My "itty-bitty European Country" produces cars of which you, rev drone, would be very proud to own one, I think....( only joking ) In Europe there are REAL Countries. But in your "Super-Mega-US Continent" there are "only" so called "States". But this will also happen to us soon. Fuck this ! Name: EU - you know ? To all US residents ( including rev drone, of course ! ): Read the post above, and you should know why I´m writing this. Don`t be angry about me ! But if someone write such things, I will answer it, of course. We ALL should stop these itty-bitty (TM) "political fights" at the HIVE. So, let`s return to the main topic ! ------------------- APOPLEX
alpha NewBee	posted 01-19-2000 03:27 PM drone... how are you planning to go vanillin --> piperonal?
ChemHack Hive Bee	posted 01-19-2000 07:11 PM You Europeans are gonna hafta change yer name from "European Union" to "Union of Europeans" or something else entirely. The reason is that EU has already been taken by: Los Estados Unitos We own it already. Yeah. Roll Baby Roll !!! PS: We know you don't live in France, Frenchies make junky autos. PSS: Just so I put something here on topic I will ask a question: How would ya decontruct cubebin without doing too much damage? How to make sure it breaks where you want?

All times are CT (US)	next newest topic \| next oldest topic
Administrative Options: Close Topic \| Archive/Move \| Delete Topic
	Hop to:

Contact Us | the Hive